Latency locus complements MicroRNA 155 deficiency in vivo.

نویسندگان

  • Sang-Hoon Sin
  • Yong Baek Kim
  • Dirk P Dittmer
چکیده

MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155.

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عنوان ژورنال:
  • Journal of virology

دوره 87 21  شماره 

صفحات  -

تاریخ انتشار 2013